Structural Control and Functional Diversification in Metal Coordination Polymers through Ligand Engineering
Main Article Content
Abstract
Copper-based coordination polymers (Cu-CPs) have emerged as a versatile class of materials with tunable structural and functional properties. The introduction of secondary auxiliary ligands plays a critical role in regulating coordination geometry, framework topology, and supramolecular interactions, which in turn influences biological activities such as urease inhibition. This study analyzes the effects of ligand geometry and steric constraints on the structural features, crystal stability, and electronic characteristics of Cu-CPs. In particular, “V”-shaped auxiliary ligands promote two-dimensional layer formation, enhance interlayer interactions, and optimize active-site accessibility, leading to improved urease inhibitory efficiency. The relationship between structure and activity is further supported by electronic considerations, including orbital distribution and potential coordination interactions. The findings highlight the importance of rational ligand design as a strategy for optimizing both structural and functional performance, and provide insight into potential applications in medicine, catalysis, and environmental remediation.
Article Details
Issue
Section
How to Cite
References
1. F. Ding, C. Ma, W.-L. Duan, and J. Luan, "Second auxiliary ligand induced two coppor-based coordination polymers and urease inhibition activity," Journal of Solid State Chemistry, vol. 331, pp. 124537–124537, 2023, doi: 10.1016/j.jssc.2023.124537.
2. F. Ding, N. Su, C. Ma, B. Li, W.-L. Duan, and J. Luan, "Fabrication of two novel two-dimensional copper-based coordination polymers regulated by the 'V'-shaped second auxiliary ligands as high-efficiency urease inhibitors," Inorg. Chem. Commun., vol. 170, p. 113319, 2024, doi: 10.1016/j.inoche.2024.113319.
3. L. Gao and A. Zhang, "Copper-instigated modulatory cell mortality mechanisms and progress in oncological treatment investigations," Front. Immunol., vol. 14, p. 1236063, 2023.
4. Z. F. Hu, Z. L. Chai, Q. Zhou, L. C. Feng, W. K. Dong, and Y. J. Ding, "The first salamo-type mixed-ligand Cu(II) coordination polymer: synthesis, crystal structure and theoretical studies," J. Mol. Struct., vol. 1287, p. 135709, 2023.
5. Z. H. Guo, L. Q. Yang, Q. G. Zhai, G. P. Yang, and Y. Y. Wang, "Molecular-Rotor-Engineered Metal–Organic Frameworks with Various Interpenetrated Degrees/Modes Featuring Tunable Porosity/Stability for Binary/Ternary C2H2/CO2/C2H4 Separation," Angew. Chem., 2025, doi: 10.1002/ange.202519278.
6. Y. M. Khetmalis, M. Shivani, S. Murugesan, and K. V. G. C. Sekhar, "Oxindole and its derivatives: A review on recent progress in biological activities," Biomed. Pharmacother., vol. 141, p. 111842, 2021.
7. Ö. Güleç, C. Türkeş, M. Arslan, Y. Demir, B. Dincer, A. Ece, and Ş. Beydemir, "Novel beta-lactam substituted benzenesulfonamides: in vitro enzyme inhibition, cytotoxic activity and in silico interactions," J. Biomol. Struct. Dyn., vol. 42, no. 12, pp. 6359–6377, 2024.
8. D. Li, A. Yadav, H. Zhou, K. Roy, P. Thanasekaran, and C. Lee, "Advances and applications of metal-organic frameworks (MOFs) in emerging technologies: a comprehensive review," Global Challenges, vol. 8, no. 2, p. 2300244, 2024.
9. G. Xie, W. Guo, Z. Fang, Z. Duan, X. Lang, D. Liu, G. Mei, Y. Zhai, X. Sun, and X. Lu, “Dual‐Metal Sites Drive Tandem Electrocatalytic CO2 to C2+ Products,” Angewandte Chemie, vol. 136, no. 47, p. e202412568, 2024, doi: 10.1002/ange.202412568.